منابع مشابه
Membrane protein stabilization
sequences is therefore important for characterizing immune responses, but it cannot describe the state of cells within a given clone. Teichmann and colleagues present TraCeR, a tool that allows TCR sequences to be reconstructed from single-cell RNA sequencing data from T cells. The approach combines immune profiling with information on fate and function based on the expression of thousands of g...
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Heteronuclear NMR relaxation measurements and hydrogen exchange data have been used to characterize protein dynamics in the presence or absence of stabilizing solutes from hyperthermophiles. Rubredoxin from Desulfovibrio gigas was selected as a model protein and the effect of diglycerol phosphate on its dynamic behaviour was studied. The presence of 100 mM diglycerol phosphate induces a fourfol...
متن کاملProtein stabilization by naturally occurring osmolytes.
Natural selection is believed to be an unforgiving and relentless force in the evolution of life on earth. An organism that cannot adapt to a changing environment or an environment hostile to cell functions is at risk as a species. So it is important to understand the mechanisms used by plants, animals, and microorganisms in adapting to environments in the biosphere that would ordinarily denatu...
متن کاملInducible protein stabilization system in Leishmania mexicana.
Targeted regulation of protein levels is an important tool to investigate the role of proteins essential for cell function and development. In recent years, methods based on the Escherichia coli dihydrofolate reductase destabilization domain (ecDHFR DD) have been established and used in various cell types. ecDHFR DD destabilizes the fused protein of interest and causes its degradation by protea...
متن کاملTandem facial amphiphiles for membrane protein stabilization.
We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.
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ژورنال
عنوان ژورنال: Transfusion Medicine and Hemotherapy
سال: 2007
ISSN: 1660-3796,1660-3818
DOI: 10.1159/000104678